Liverpool boss Brendan Rodgers may have managerial experience of Europa League competition in his career history, but competing in the Champions League is an altogether different experience.
Also, the Ulsterman may find it an arduous task to replicate the success of last season should he use the same formula of fielding the same starting XI week in, week out.
That is, according to renowned Sky Sports analyst Gary Neville, who looks ahead to the Reds's trip to Switzerland as Liverpool take on FC Basel in the second round of Group B fixtures on Wednesday evening.
"He's got a different manager problem [now]," said Neville.
"In Europa League you prioritise the Premier League but in the Champions League it's hard to do that."
He continued by remarking on Rodgers's aggressive summer recruitment drive that saw an abundance of varied talent arrive at Melwood, seemingly off-setting the loss of Luis Suarez, who transferred to FC Barcelona in one of the transfer window's biggest deals.
"Rodgers has a better squad but the question is if he has a better team… the loss of Suarez is big.
"The loss of [Daniel] Sturridge [to injury] has also hampered them," he said. "Will he be back for Basel? I expect Liverpool to at least get a point.
"It's been a struggle for them the past few weeks and Rodgers has had to juggle a lot of balls. This competition is the benefit and reward for last season but they cannot keep playing the same XI like it seemed Liverpool were doing last season."