Roma have made a perfect start to the season, but they face an enormous fortnight and could miss some key men.
Rudi Garcia's side beat Verona 2-0 last weekend on Francesco Totti's birthday and maintained their 100 percent record this season.
But Roma now take on Manchester City away on Tuesday evening, followed by a trip to Italian title rivals Juventus, who are yet to concede a goal, on October 5.
The Giallorossi are preparing to call upon back-up Lukasz Skorupski for the game against City and Garcia may need to shuffle the deck a little.
Roma are returning to the Champions League after two years and may find it difficult to adapt to the pace while keeping their title challenge going.