AC Milan boss Pippo Inzaghi is being tipped to choose Fernando Torres and Marco van Ginkel from the off against Empoli.
The Rossoneri are hoping to bounce back from a 1-0 defeat at the hands of Juventus and recapture the form that saw them beat Lazio 3-1 and Parma 5-4.
Fellow Chelsea owned man van Ginkel may also be handed a chance to impress with Jeremy Menez, who has made an impressive start to the season, on the left and Keisuke Honda on the right.
Newly promoted Empoli don't have a lot to show for their start to the campaign, but they haven't been pushovers by any means.
Roma had to fight hard to squeeze past them 1-0 and they drew 2-2 with fellow new boys Cesena last weekend.
Torres started life with Milan in their defeat against Juventus - a tough start given that the Old Lady are yet to concede this season - and the Spaniard will be determined to open his account against a more forgiving defence.