The Whites took the lead in the 20th minute when Mirco Antenucci found Rodolph Austin to shoot home from the right side of the box with his right foot.
Visiting Huddersfield came close to equalising through Jonathan Hogg and Harry Bunn, but it was Leeds who scored the second goal of the match through Antenucci on the stroke of half time.
Mark Hudson had two good chances for Huddersfield in the opening minutes of the second half, but his headers were not on target.
Leeds made it 3-0 on 69 minutes when Souleymane Doukara shot home from close range after collecting a pass from Austin.
The hosts ended the game with 10 men, though, as Gaetano Berardi was sent off for a second bookable offence on 73 minutes, but that did affect the final outcome.
The win lifts Leeds up to 11th in the Championship with 13 points from eight matches, while Huddersfield are third from bottom with just five points.
Below are the best pictures of the match: