The latest Queens Park Rangers news, views and rumours...
The 67-year-old worked with the former England striker during his time at both Portsmouth and Tottenham Hotspur and Defoe could be available in the winter.
Defoe would ideally partner another of Redknapp's old strikers: Peter Crouch.
The Rs boss defended Hughes' tenure at Loftus Road and said it was a 'difficult time' for the Welshman.
“When you go so many games without winning you’re walking into a difficult situation. There were lots of different groups at the club," Redknapp told reporters.
“I’m sure that’s not all down to Mark. There were players here he inherited and others came in — you never get a perfect group. It was a difficult time for him."
Meanwhile, Redknapp has confirmed that Rob Green will start against Stoke - and will remain QPR's no.1 for the foreseeable future.
He did, however, admit that Alex McCarthy, signed from Reading this summer, has 'a big future' at the club.
"Rob will start tomorrow,” the Rs boss is quoted as saying by West London Sport.
“Alex will bring competition for the goalkeeping spot, which is good, and I think he’s got a big future.”