The standout fixture this weekend sees Chelsea travel to Manchester City on Sunday afternoon in a huge game, but one that is difficult to call from a fantasy perspective.
Liverpool travel to West Ham United on Saturday evening, while Manchester United take on Leicester City as Louis van Gaal's side look to build on their 4-0 win against Queens Park Rangers last time out.
Tottenham Hotspur and Everton have home games that they will expect to win against West Bromwich Albion and Crystal Palace respectively, and they are the two sides who ould see their players score the most fantasy points this weekend.
DEF - Leighton Baines - Everton
Baines is an expensive option, but one that should repay owners as the Toffees play Palace at Goodison Park this weekend. The left-back scored a penalty in Thursday night's 4-1 win against Wolfsburg in the Europa League, and his set-piece exploits make him an ever-attractive option in defence. Palace conceded three in their last away game against Newcastle United, and Everton will look to make it two clean sheets from two on Sunday.
DEF - Danny Rose - Tottenham
Another left-back to consider this weekend is Spurs man Danny Rose, as he still remains Mauricio Pochettino's first-choice for the starting role ahead of Ben Davies. He will be fresh for Sunday's game against West Brom, having been rested for the Europa League game against Partizan Belgrade on Thursday. Rose's attacking play down the left make him the most attractive option in a Spurs defence that will hope to shut out the Baggies this weekend.
MID - Aaron Ramsey - Arsenal
Arsenal travel to Aston Villa on Saturday afternoon and will hope to be the first team to beat the Villans so far this season. Ramsey will hope to shine and his ability to break forwards when Arsenal attack make him an attractive option once again this weekend. The Welshman hasn't scored since the 2-2 draw at Everton, but he will look to get on the scoresheet once again this weekend.
MID - Christian Eriksen - Tottenham
Eriksen came to life in Spurs' 2-2 draw at Sunderland last week after a relatively slow start to the new campaign, and he will look to build on his goal in that game when he lines up against West Brom on Sunday. The Baggies have conceded five goals in their last two games, with four of those goals coming from attacking midfield players. Eriksen's added threat from set-pieces make him the most attractive option in the Spurs midfield this weekend.
FOR - Graziano Pelle - Southampton
Pelle has scored three in his last two and will look to extend that record when the Saints travel to Swansea on Saturday. The Italian has looked sharp in and around goal, and he will spearhead an exciting Southampton attack once again this weekend. Swansea shipped four at Chelsea last week and struggled to contain Diego Costa - who netted a hat-trick - and Pelle's similar playing style could see him cause all kinds of problems against Garry Monk's side.