One goalkeeper suspended, another injured, Liverpool will be facing a side with their third-choice goalkeeper starting the game.
The Bulgarian's champions' first choice goalkeeper Vladislav Stoyanov is suspended which made their progression to the group stages all the more memorable after their defender Cosmin Monti went in goal for the penalty shootout victory over Steaua Bucharest.
Their second-choice stopper Ivan Cvorovic has since picked up a shoulder injury in training but the Ludogorets boss seems to be confident Georgi Argilashki can fill the void adequately despite not playing a league game for the side.
Liverpool are heavy favourites going into the clash given that Ludogorets are relative unknowns on the European stage. The Reds had a disappointing result against Aston Villa on Saturday and members of the squad, including manager Brendan Rodgers, have been speaking of their desire to put things right tomorrow evening as they look to bounce back with a win and get their Champions League campaign off to a winning start.
Ludogorets, however, will be looking to spoil the home side's return to the Champions League and cause a surprise at Anfield.