Dortmund are missing star player Marco Reus for Arsenal's Champions League visit, but close attention will have to be paid to striker Adrian Ramos.
The Bundesliga side signed Ramos from competitors Hertha Berlin in the summer after he scored an impressive 16 goals in the top flight in 2013/14.
This season to date he has two goals in one Bundesliga start and one substitute appearance, turning in a superb display at the weekend.
Ramos, who hails from Colombia like Manchester United's Radamel Falcao, scored one, created one, and provided four key passes in the weekend win over Freiburg.
The striker was playing in the furthest forward position with Pierre-Emerick Aubameyang shifted wide as Jurgen Klopp adapted his side to re-integrate summer signing Shinji Kagawa.
The 28-year-old is full of confidence as he builds on last season's displays, and seeks to show he can replace the prolific Robert Lewandowski.
The chance to play in the Champions League is an opportunity Ramos has been waiting for, with former coach Jos Lukhakay commenting at the end of last season:
"He earned this. He wanted to be competing for the title and in the Champions League. That's not something we could offer him. He is one of the Bundesliga's outstanding players."
With Arsenal's defence stretched with injury, Ramos' power will provide a stern test for Laurent Koscielny and Per Mertesacker and hold their attention.
With Wojciech Szczesny speaking about his determination for Arsenal to improve defending set pieces this week, the aerial threat Ramos has to offer could be a real examination of their resolve, if he gets the nod to start against the Premier League side.