But the 28-year-old Colombia striker will not be the only South American making his Premier League debut this weekend. There is also Marcos Rojo, whose best form will likely be required to shore up Man United's defence.
Even then, however, there is still another South American import who could make his bow in Manchester. And, with all the attention on United's new signings, his prospective debut has largely gone unnoticed in the build-up to Sunday's clash.
That man is Eduardo Vargas - and he could just provide QPR with the creative spark they've been craving so far this term.
The Chilean joined the west London side on a season-long loan deal in August but has only received his work permit this week. However late the news has come, though, Harry Redknapp will be delighted to welcome the 24-year-old into his first-team plans.
And for one so young, the forward could have a bright future ahead of him. It hasn't quite worked out for Vargas in Napoli but the Chilean need only look to Philippe Coutinho for inspiration in that regard. The Brazilian fell into obscurity at Inter Milan but has made a real name for himself since moving to Liverpool.
QPR, meanwhile, have scored just once so far this campaign and the opportunity is there for Vargas to help change that. The Theatre of Dreams may be an intimidating venue but that didn't stop Swansea City from leaving Manchester with three points on the opening day of the season.
While all eyes will be on Falcao, then, it is another South American that has the opportunity to steal the show on Sunday. Perhaps the 28-year-old can take all the plaudits with a perfect hat-trick against the Rs but, even then, the watching world will have expected something of the like from the Colombian.
Vargas, though, has nothing to lose - which makes the prospect of his debut all the more exciting for QPR fans.