Rose spent a season on loan at the Stadium of Light two years ago and thrived under Martin O'Neill and Paolo Di Canio as he was named the club's young player of the season.
The spell at Sunderland saw Rose shine in the Premier League and he has been Tottenham's first-choice left-back ever since as a result.
Rose scored one goal in 27 Premier League appearances during his time on Wearside but will hope to seal victory with Spurs when the two sides meet on Saturday afternoon.
“It will be a hard game, as they always are up there. They have changed a lot of personnel since I was there but I think it will be a different game to the 5-1 victory we had at White Hart Lane last season.
“Our goal as a team, no matter who we play against, is to try and keep a clean sheet and we'll be looking to try and rectify our result and performance against Liverpool," he said.
Sunderland have yet to win a game this season, and they will be hoping to improve on their 1-0 loss at Queens Park Rangers last time out.
While Spurs will be desperate to get three points after their 3-0 thumping by Liverpool two weeks ago, and their recent record against Sunderland should give them confidence.
Spurs have won six of the last seven meetings between the two sides, and have left the Stadium of Light with three points in three of the past four games, winning 2-1 on each of those occasions.