City boss Manuel Pellegrini has confirmed that Fernando will be ruled out for up to two weeks, whilst Stevan Jovetic suffered a hamstring injury on international duty with Montenegro.
This means that Edin Dzeko could line up alongside Sergio Aguero in attack whilst Fernandinho and Yaya Toure are likely to line up in the middle of the park for the Champions.
Fernando will also miss City's trip to Bayern Munich in the Champions League in midweek, as well as next weekend's Premier League clash with Chelsea at the Emirates Stadium. He could also miss City's League Cup tie against Sheffield Wednesday, but may return for their meeting with Hull City at the KC Stadium on September 27.
The side will be hopeful Jovetic returns soon given his impressive start to the season, and following Alvaro Negredo's departure to Valencia in the summer.
The City manager explained his reasons for allowing Negredo to leave, saying: "The decision for Negredo to go was very important. We have a restriction on the players we can use in the Champions League. Alvaro Negredo was injured. He wasn't going to be on the list. He wanted to go back to Spain. It all starts from the restrictions due to the money we spent."
Pellegrini conifrmed that Pablo Zabaletta is fit enough to play after picking up a knock whilst Frank Lampard and defender Eliaquim Mangala are both included in the squad for tomorrow's game.