Ferdinand left United after 12 highly successful years this summer to join former manager Harry Redknapp at promoted side Queens Park Rangers, but he will return to Old Trafford to take on a new-look United side this weekend.
The 35-year-old has started all three games for QPR this season and helped the side to their first clean sheet and win against Sunderland last time out.
And although the prospect of facing an devastatingly talented United forward line will be a tough test for the experienced centre-back, his manager still believes he has what it takes to cope with the demands.
"Rio will not be fazed by it at all. It will be an emotional day of course, he is an absolute legend at that place and rightly so.
"But he is still one of the best defenders in Europe. He is a fantastic footballer and facing Falcao will be seen as a challenge, nothing to be frightened of," Redknapp said, speaking in his column for The Sun.
"Rio is a top professional and he could still get into the United team, absolutely he could. When he was 14 or 15 I said then he would go on to be one of the best defenders in Europe.
"He did that and more and is still an absolutely superb football player," Redknapp added.
Louis Van Gaal's side have yet to win a game this season, and following the acquisition of Radamel Falcao on deadline day, the Reds could start with their new-look attack against the R's on Sunday.
But Redknapp isn't too concerned about the prospect of facing Wayne Rooney, Juan Mata, Robin Van Persie, Angel Di Maria and Radamel Falcao, and believes this nothing new when preparing side's to face the Red Devil's at Old Trafford.
"I have been going to Old Trafford for years as a visiting manager to face frightening forward lines, and have still managed to get a few results off them.
"In the past they have had the likes of David Beckham, Ryan Giggs, Teddy Sheringham, Ole Gunnar Solskjaer, Dwight Yorke, Eric Cantona, Cristiano Ronaldo.
"This isn't exactly a new phenomenon is it?
"But I have faith in my players too. We're clearly not the favourites to win but we have got out first win of the Premier League season now and that's really helped with the confidence."
Will United get their first win of the season against QPR on Saturday? Could Rio Ferdinand still get into the United team?