Manuel Pellegrini's side were enjoying a strong start to the season after 2-0 and 3-1 wins over Newcastle United and Liverpool, but last weekend's shock 1-0 defeat at home to Stoke City has raised question marks over their ability to retain their Premier League crown.
Their hopes of bouncing back from that defeat to the Potters has taken a hit after the news that talismanic centre back Vincent Kompany has suffered a calf injury whilst on international duty with Belgium this week, and had a scan today to reveal how long he will be out for - the results of which have yet to be released.
City have to be hoping that he will be back for their next match on September 13th as they look to rebound from that defeat to Stoke - which may not have been quite so hard had the fixture not been against title rivals Arsenal.
The Gunners famously capitulated against their top four rivals last season, and their 6-3 defeat to City still lives long in the memory as Pellegrini's men carved through the Arsenal defence at will - and whilst the two sides played out a 1-1 draw later in the season, Arsene Wenger will be looking for his side to exert some revenge when the two teams meet at the Emirates Stadium on the 13th.
The additions of Alexis Sanchez and Danny Welbeck for a combined £48m should provide a boost to Arsenal's attack - which makes Kompany's injury all the more important.
Should the Belgian miss the game, then it will be down to either Matija Nastasic or Eliaquim Mangala to partner Martin Demichelis in the heart of the City defence. Demichelis is notoriously slow and could have issues tracking the movement of Sanchez and Welbeck, whilst Nastasic has barely played in the last 12 months and Mangala is being gradually eased into Premier League life.
Kompany's absence could leave City's defence in a state of flux - and the pace of Welbeck and Sanchez could leave them exposed, and leaving the Arsenal duo licking their lips at the prospect of beating City and laying down a message to their title rivals.