The Super Bowl champions open up the new season on Thursday night against the Green Bay Packers at CenturyLink Field and will be hoping to change a recent trend and get their season off to the perfect start.
The NFL Kickoff game marks the start of the new season and has been in place since 2002, and since 2004 the opening game has featured the Super Bowl champions.
The first eight games featuring the champions saw the Vince Lombardi Trophy winners seal victory in the opening game, though in the last two years it has all changed.
In 2012 the New York Giants became the first Super Bowl winners to lose the Kickoff game as they lost 24-17 to the Dallas Cowboys in the only Kickoff game that was played on a Wednesday due to the fact that the Democratic National Convention was taking place on the Thursday.
Then last season, the Baltimore Ravens became the second team to lose the Kickoff game having won the Super Bowl just months before.
The Ravens had to play away at Denver because of scheduling problems conflicting with MLB as the Baltimore Orioles were set to play at home on the same night.
The Broncos won the game 49-27 and they went on to play in last year's Super Bowl before being torn apart by the Seahawks in New York.
Seattle destroyed Denver to win 43-8 in February to claim their first Super Bowl win in franchise history and they will hope to buck the trend of losing champions in the season opener when they host Green Bay on Thursday night.
The Seahawks are expected to go far once again this season and are favourites to retain their crown at champions at the end of the 2014 season.
Thursday's opener will see the Seahawks play in the first game of the season for the first time, whilst opponents Green Bay will be appearing in their second after they won the 2011 Kickoff game against the New Orleans Saints.
Will Seattle change the recent trend and win Thursday's opening game?