Why 22? The Brit won the 2009 World Championship with it on his Brawn GP car and chose it as his permanent number ahead of the 2014 season.
But we're getting ahead of ourselves. Button made his F1 debut with Williams as a 20-year-old after beating the team's test driver, Bruno Junqueira, in a shoot-out for the seat. At the time Button's single-seater experience was limited to a season a piece in Formula Ford and British F3.
He showed well in his early races, finishing a superb fifth in his first British Grand Prix at Silverstone. However, despite 15 years of trying, he is still yet to stand on the podium at his home race, with fourth-place finishes in 2004, 2010 and 2014 his best result.
After scoring a season's best fourth-place finish at the German Grand Prix, Button earned yet more plaudits by taking third on the grid at Spa. The following day he added to his points tally with a mature drive to fifth spot. Further points in Japan capped a brilliant debut year which saw Button finish eighth in the standings.
But with Williams already committed to running Juan Pablo Montoya the following season Button was left searching for a new home. He landed at Benetton, but this would prove a difficult gig. The outfit was in transition, the car was off the pace, and his team-mate Giancarlo Fisichella was on top form. Button scored points just once in 2001, taking fifth in Germany, and dropped to 17th in the standings.
In 2002 the team became Renault and Button was joined by Italian one-lap specialist Jarno Trulli. The season marked a return to form for Jenson, who was a regular top-five finisher and ended the year seventh in the World Championship. However he would once again be moved aside for his team's reserve driver, with a young Fernando Alonso replacing him at the Anglo-French squad.
That meant yet another move, with Button becoming a BAR driver for 2003. The campaign was largely successful, with Jenson picking up points on a regular basis. However he did suffer a frightening shunt that forced him to miss the Monaco Grand Prix (below) and, after four years of trying, was still yet to secure a maiden podium.
That would all change in 2004. Though Ferrari and Michael Schumacher still dominated, Button's BAR squad had the second fastest car on the grid, putting the Brit in real contention for top-three finishes.
In total he scored 10 podiums over the course of the season, the first in Malaysia, as well as pole position at the San Marino Grand Prix.
At Monaco he finished a close second to former team-mate Trulli after harrying the Italian throughout the latter stages. It was to be one of three runner-up finishes that year and helped him to finish third in the World Championship. The next objective was a maiden win.
2005 was a less successful year. The BAR squad were disqualified from the San Marino Grand Prix and subsequently banned from two race for using an illegal fuel compartment which allowed their cars to run underweight. Nevertheless, Button managed a brace of podiums later in the season to salvage some respect for the team.
In 2006 BAR were bought out by engine partners Honda and it was in this guise that Button finally scored his first grand prix win, triumphing in a topsy-turvy race in Hungary. Two further podiums and a strong run of points late in the season saw him take sixth in the standings.
But his breakthrough 2006 would soon become a distant memory. The 2007 Honda was as slow and unreliable as its paint-job was ugly, and Button managed just six points all year on his way to 15th in the standings. That was still a lot better than veteran team-mate Rubens Barrichello, who recorded no points over a season for the only time in his long career.
2008 was worse still, with Button scoring only three points and finishing a career-low 18th in the World Championship. Such was the scale of the disaster, Honda elected to ditch the project at the end of the season, putting Button's future in the sport in doubt. Only a last minute management buyout, led by Ross Brawn, could save the team and begin what would be a fairytale season for Button.
With the team saved and Honda's under-performing engine replaced by a Mercedes unit it soon became clear that the Brawn GP car was the class of the field. Button won six of the opening seven races to build a huge World Championship lead.
His dominance ebbed over the second half of the campaign, but the hard work done in the opening races meant Button was able to seal the title with fifth in Brazil.
Almost a decade after making his debut, and after plenty of turbulent times, Jenson Button was World Champion.
With Brawn becoming Mercedes for 2010 Button switched to McLaren, joining Lewis Hamilton in an British superteam. Jenson didn't take long to get his first win for the Woking-based squad, triumphing at round two in Australia. He'd pick up another win in China, plus five more podiums, to end the season fifth.
In many respects 2011 was Button's most impressive in F1. The Red Bull of Sebastian Vettel was untouchable, but Jenson mixed consistency with speed to finish as runner-up to the young German. He was often the only man capable of beating Vettel, with his stunning last-gasp victory in Canada the pick of his three triumphs that year.
He secured three more wins in 2012, including a dominant performance at Spa, to take another fifth-place finish in the standings. Impressively, Button had out-scored departing team-mate Lewis Hamilton over their three seasons together.
Having won the final race of 2012 Button came back down to earth with a bump in 2013. The new McLaren was nowhere near race-winning pace, leaving Jenson to scrap for minor placings. The team subsequently went the whole campaign without a podium, marking their worst performance in 30 years.
His racing woes were put into perspective over the winter when Button's father John passed away. Button Sr. had missed only one grand prix since his son's debut and was a big part of Jenson's life both on and off the track.
Button remains a McLaren driver in 2014, but despite some solid displays his future remains uncertain. A number of drivers have been linked with his seat, leading Jenson to admit that his career may be drawing to a close.
When he does hang up his helmet, Jenson can look back on a very successful grand prix career that has seen both highs and lows in a rapidly-changing Formula 1.