Alvaro Negredo was loaned out to Valencia on deadline day and the Premier League champions failed to bring in a replacement.
Negredo's City departure may have come as a surprise to many especially when you consider it was only two months ago that the 29-year-old expressed his desire to stay with the Citizens.
Nicknamed 'the beast', Negredo only joined Manuel Pellegrini's side last summer in a £20 million deal from Sevilla. His career in Manchester started very well too, he formed a formidable partnership with Sergio Aguero during the first half of the season, but and injury and drop in form hampered him during 2014.
Despite the deal with Valencia only initially being a season-long loan, it's unlikely City fans will ever see the striker, who quickly became a favourite with the Etihad crowd, pull on their shirt again. When his loan ends at the end of this season the La Liga side have an obligation to sign him for permanently for £24 million.
It was thought and reported last Saturday night that City were desperately trying to work out a deal that would see Radamel Falcao come in, without breaking and FFP restrictions. However it never came to fruition and the world class Colombian opted for local rivals Manchester United instead.
This lack of replacement has left City with potentially a severe problem upfront. Sergio Aguero, Edin Dzeko and Stevan Jovetic are now the club's only senior strikers, and in each league game this season they have played with two forwards, leaving the third on the bench.
Despite being arguably one of the greatest strikers in the world, Sergio Aguero is also one of the most injury prone, as is his strike partner Stevan Jovetic. The Argentine's last two seasons have been disrupted by injuries to his knee, calf and hamstring, whilst Jovetic only managed 11 league appearances during his debut year as a result of injury.
Swedish youngster John Guidetti is still at the club having seen his but his proposed loan move to Celtic collapse, but he has never proven himself in the Premier League despite a loan spell with Stoke City last season. It also emerged earlier today that he might still join the Scottish club as they have appealed to FIFA to make an exception for the transfer.
Whilst it's true that Pellegrini's squad has enough strength in depth that they can alter their system to accommodate just one forward, it just seems daft that the two-times Premier League champions would leave themselves in such a risky position, even if Negredo desperately wanted to leave.
City fans will be praying that the club can keep their star strikers fit all season, otherwise defending their Premier League crown and competing in Europe will be extremely difficult this season.