Tottenham's record signing has been recalled by the World Cup finalists as captain and talisman Lionel Messi misses out.
The former Roma forward had looked like he might sneak into his country's World Cup squad this summer despite disappointing form during his first season at White Hart Lane, only for a back injury to rule him out of the running.
With compatriot and former Argentina international Mauricio Pochettino's arrival as coach at Tottenham before the start of the campaign, it was believed that the skilful 22-year-old would be able to develop during this second season, and so it has proved with a couple of eye-catching performances during Spurs' opening games.
With Barcelona and Argentina icon Messi one of several World Cup players who have pulled out of former Barca boss Gerardo Martino's opening squad, Lamela will be eager to make an impression in a game against the side that broke his nation's hearts in the final in Rio six weeks ago.
Lamela has won 6 caps for Argentina having made his debut in 2011. He made just 17 appearances for Spurs last season as a loss of form and various injuries undermined his debut season, though the winger has already featured in the majority of his club's opening fixtures.