The Reds were paired with the defending champions during yesterday's draw, as well as FC Basel and FC Ludogorets.
Far from being fearful, however, Skrtel is relishing a tie against the Spanish giants, especially as Liverpool beat them 4-0 the last time the two sides met.
"The draw was alright for us," the 29-year-old told Liverpool's official website. "We got Real, who are one of the biggest favourites for the Champions League - and I was wishing we'd get them, so I'm quite happy about that.
"Then we have Basel, who are a good team, and Ludogorets Razgrad, who will be tough. But I think - and hope - we can beat them and get to the next stage.
"[Real Madrid] are one of the biggest teams in the world, so it's a great thing to play against them and in a stadium like the Santiago Bernabeu.
"It's going to be a great game for the fans and players, so I'm looking forward to it. We beat them away [in 2009] and then the game at Anfield when we beat them 4-0 was a great night for us.
"Obviously both teams are different now but they're going to be interesting games."
|Team||Pos||Accurate Passes||Tackles Won||Aerial Duels Won||Apps||Mins|
As Opta stats show, Skrtel has made a considerable amount of accurate passes in his opening two Premier League games and won several aerial duels.
Liverpool's overall defensive form will have to improve, though, as four goals conceded in two games (one against Southampton, three at Manchester City on Monday) will not get them very far either at home or in Europe.
Especially when Real Madrid come to town.