If the Gunners concede against Besiktas in the second leg of their Champions League play-off and don't score more than once in return, they will go without football at Europe's top table for the first time in what seems like forever.
Just the occasion for someone like Ramsey, whose never-say-side attitude helped the north London side claw back a 2-2 draw when they were 2-0 down at Everton on Saturday.
However, Arsene Wenger does have considerable firepower in his side with the likes of Mesut Ozil, Alexis Sanchez and more - and Ramsey is backing them to get past a Demba Ba-led Besiktas.
The Welshman was sent off in the closing stages of the first leg and will miss tonight's clash at the Emirates Stadium through suspension.
Next up for Wenger's men is a trip to Leicester City in the Premier League on Sunday.
Before that, should they knock Besiktas out, they will take part in tomorrow's draw for the Champions League group stages.
Arsenal have amassed four points from their opening two league games but drew 0-0 in Turkey last week.
That means the Gunners will be forced into extra-time with a 0-0 draw this time around and so must score to ensure progression within the 90 minutes. It's make-or-break.