The Red Devils endured the misery of the dismal David Moyes era last summer, which ended in a seventh place finish despite the Scot being sacked in April. In his place comes Louis van Gaal, the former Barcelona and Bayern Munich boss who guided an unheralded Netherlands team to the semi-finals of the World Cup in Brazil this summer.
There is a certain degree of expectation surrounding United given van Gaal's track record of success throughout his long managerial career, and the 62-year-old is reportedly targeting the Premier League crown despite last season's respectively lowly finish.
It may be unlikely given the work that still needs doing to the United squad, but what one question do the Red Devils need to answer in order to win the Premier League?
Can van Gaal get the best out of United's failing stars?
Under Moyes, United were turgid. Their approach play was simply crossing the ball in ad nauseam, whilst a number of players experienced their worst seasons to date. Juan Mata couldn't find his role in the team having arrived from Chelsea, Robin van Persie spent most of the season either short of form or short of fitness, whilst the defence looked all at sea too regularly.
Now, van Gaal comes in with a 3-4-1-2 system which served him so well at the World Cup. Players are learning on the job, but it makes sense; Juan Mata gets to play in behind two strikers, with Wayne Rooney pushed further up the field. So far, the players look to have adjusted very well, which bodes well for the Premier League season.
Ultimately, some players took a step back last season; Phil Jones, Chris Smalling and Ashley Young had their worst seasons at Old Trafford so far, and now with new roles and responsibilities under van Gaal, all three will be expected to improve this season.
If van Gaal can get more out of some of United's squad players, then a better season will be on the cards - and under the Dutchman, who would really bet against a title challenge?