With Luke Shaw being ruled out for four weeks with a hamstring problem, it is very likely Manchester United will go all out in their chase of Sporting Lisbon's Marcus Rojo and Ajax's Daley Blind in the coming days.
Shaw joined United for £27 million from Southampton this summer, having been with England on their disappointing World Cup campaign.
He had featured regularly in the club's preseason games, but did not play in the 2-1 win over Valencia because of his injury.
Sporting Lisbon's Marcus Rojo has been heavily linked to Old Trafford after United were revealed to have made a bid for the Argentine star. The player even threatened to go on strike to force through his move, with the Sporting then discipling the 24-year-old. Though their are tensions between the player and the Portuguese club, there is every chance the Reds could offer enough money to convince Sporting to sell.
Alternatively, or additionally depending on how many players Van Gaal wants, Daley Blind has been linked with joining up with his old national team boss, having starred for the Netherlands in Brazil. Blind, who has already started the domestic season with Ajax, has himself admitted he would find such a move hard to refuse, and having proved himself at the World Cup, he would be a welcome addition that could also fill in at centre back and defensive midfield.
United have very little cover at left back, with Patrice Evra having headed to Juventus and his understudy from last season, Alexander Buttner, now at Dynamo Moscow.
It may ensure Van Gaal continues with his system of United playing three at the back, with Ashley Young possibly in line to take that wide left position for the next few games. Alternatively, Jonny Evans or Rafael could play out of position covering for Shaw.
But with the young Englishman set to miss several games, and hamstring injuries notoriously difficult to manage, there is every likelihood that Van Gaal could up his chase for at least one of his two defensive targets ahead of Friday's deadline for the game with Swansea.