Former Bluebirds striker Rudy Gestede starts up front for Rovers, while Craig Conway, who also had a spell at the club, starts on the wing.
Cardiff, with their huge squad to choose from, have gone for what looks like a 4-3-3 formation, with Matthew Connolly and Mark Hudson the two centre-halves named in the starting line-up.
Aron Gunnarsson and Peter Whittingham will play a more defensive role in a three-man midfield, as Mats Daehli slots in behind three strikers Kenwyne Jones, Adam Le Fondre and Nicky Maynard.
The Bluebirds are looking to make an immediate return to the Premier League, having been relegated last season.
Blackburn Rovers XI: Robinson; Baptiste, Hanley (c), Kilgallon, Olsson; Cairney, Lowe, Evans, Conway; Rhodes, Gestede
SUBS: Kean, King, Dunn, Marshall, Varney, Williamson, Taylor
Cardiff City XI: Marshall, Brayford, Connolly, Hudson (c), Fabio, Whittingham, Gunnarsson, Daehli, Maynard, Le Fondre, Jones
SUBS: Moore, John, Kim, Eikrem, Adeyemi, Theophile-Catherine, Burgstaller