The Argentine is said to be a priority target for Pochettino, and Spurs are believed to be in talks for the Villarreal defender who has been previously linked with a move to Barcelona this summer.
The La Liga club reportedly want at least £20million for the 23-year-old as they owe 35 per cent of any sale to his former club River Plate, though Spurs have reportedly opened negotiations with a £16million offer.
Musacchio has made 139 appearances for Villarreal since 2010 and has scored three times for "The Yellow Submarine".
He has two Argentina caps to his name and was perhaps unfortunate not to be a part of Alejandro Sabella's World Cup squad for the tournament this summer.
Spurs are now hoping to continue their defensive restructure with the addition of Musacchio, and he would be an impressive acquisition if the Lilywhites can wrap up a deal.
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The Argentine made more interceptions and won more tackles than any of the four central defenders at Spurs last season, with only Michael Dawson making more clearances.
Younes Kaboul continued to struggle for fitness last time out and Michael Dawson's age may finally be catching up with him, so Musacchio would be an excellent addition at the perfect time.
Vlad Chiriches still has more to offer Spurs, but Jan Vertonghen will likely be the first-choice centre-back to partner Musacchio if the Villarreal man makes the switch to the Premier League.