Emilia-Romagna side Bologna were relegated from Italy's top flight last season and are trying to rebuild for life in Serie B.
Bologna are set to complete the signing of marksman Daniele Cacia, who was also on Leeds United's shopping list, and that may push Acquafresca towards Elland Road.
According to reports in Italy, Leeds are eyeing Acquafresca, who has a solid track record in Italian football but has seen his career stall somewhat of late.
And Bologna have gone some way to confirming that they are ready to listen to offers for the ex-Inter man.
"Rolando Bianchi and Acquafresca have big salaries and if they don't leave it will be difficult to sign any other strikers."
Acquafresca is reportedly valued at around £1 million but his salary demands may be quite high and it remains to be seen whether he is open to relocating to England.