The Dutchman was officially unveiled as the Red Devils' new boss on Thursday afternoon at a packed out press conference, and he immediately outlined about his plans for how he will turn around the fortunes of his side.
Van Gaal takes over from Ryan Giggs who was appointed as interim boss after David Moyes was sacked in April after a disastrous campaign that eventually finished with a seventh-place finish, their lowest-ever in Premier League history.
Yorke, who was part of the famous Treble-winning side of 1999, thinks that Van Gaal's arrival, coupled with last term's poor season will have many of the squad sweating on their place at Old Trafford.
Speaking to Sky Sports News, he said: “I think most of the players [will be worried for their place] after such a disappointing season last term - they didn’t compete for the league and haven’t done well in the FA Cup."
"The players have to take a large responsibility for their actions and their performances last season - some players will think it is a great opportunity to show what they can do for the manager."
“It’s up to the players to be ready for what Van Gaal wants to do - Lots of questions are being asked not from the manager’s point of view - Is the hunger and desire there from the players?"
However, one player Yorke feels won't be worried is striker Wayne Rooney and the former Aston Villa star thinks that the United man is still one of the club's marquee names.
“Without doubt he’s one of our better players," he added. "There was lots of criticism about [England at] the World Cup, but I thought he was one of England’s better players. But he’s one of Manchester United’s top players."
Finally, Yorke explained how he was impressed by LVG on his first dealings with the press as United boss.
He said: “He was very assertive and decisive. He’s been in that position before, he’s self-assured and he highlighted everywhere he’s been he’s been at the top clubs, Barcelona, Bayern Munich.”