The Saints got off to a fine start under Ronald Koeman as a youth-filled side cruised to a comfortable 4-0 win against lower-league Dutch outfit EHC.
The new manager changed his entire starting eleven at half-time with Sam McQueen impressing during the first 45 minutes as he scored one and created another for Callum Chambers to score before being replaced by Billy Sharp - who also scored in what was his first Southampton appearance for almost two years.
Steven Davis added the third shortly after earning the penalty which Sharp converted as the south coast club started life under their new manager in fine style.
New signing Dusan Tadic made his unofficial debut as he replaced James Ward-Prowse at halftime, but it was the youngsters that shone with Sam McQueen particularly impressive.
The 19-year-old made just one appearance for the club last season, in the 1-0 FA Cup defeat at Sunderland, but signed a four-year contract last month - a day after Koeman was confirmed as Mauricio Pochettino's replacement.
Six teenagers were included in the starting lineup as Koeman opted for a mixture of youth and experience during his first game and he will hope to build on the performance on Thursday, when they face KSK Hasselt in their second and final game in their pre-season tour of the Netherlands.