Manchester United ambassador believes prolific striker was one of the best he came across during his playing days.
Charlton was quoted by the club's official website to have said: "I was deeply saddened to hear the news of Alfredo Di Stefano's passing. As one of the stars of the legendary Real Madrid team, I think Alfredo was one of the best players I ever came across and an extremely intelligent footballer."
Born in Buenos Aires, Argentina, di Stefano spent the formulative professional years of his career at River Plate, winning the Argentinean championship twice, before a trophy-laden spell at Real where he won the title eight times and European Cup five times in a decade. He also holds the honour of scoring in five consecutive European Cup finals.
Charlton continued: "He was somebody I really respected, having watched him from the stands at the Bernabeu and then played against him. I have many fond memories of my time with Alfredo and feel privileged to be able to call him a good friend. The footballing world has lost a great player and a great man.
"I'd like to send my condolences on behalf of everybody at Manchester United to his family and our friends at Real Madrid."