Luis Suarez v Phil Jagielka
Luis Suarez's return for Uruguay is bound to give the South American side a great lifeline, he is a player who can produce a piece of magic out of nowhere. He won the Player of the Year award in England last season, as voted for by the players, so no doubt he will get the respect from the England team. Having said that, there are no secrets about where his talents lie and with him likely to face five Liverpool teammates, there will be no surprises.
It is likely Suarez will have to face Everton defender Phil Jagielka, who will know all about Suarez's talents from the Merseyside derbies over recent years. Jagielka was outstanding against Italy on Saturday, despite conceding two goals, he will need to match that performance, if not be better, against Uruguay if he is to concede less this time around. Jagielka has struggled at club form facing Suarez in recent years, but he will need to be at his best this time on the World Cup stage, hopefully with the added protection of Gerrard and co.
Edinson Cavani v Gary Cahill
Edinson Cavani has had a mixed time of it when he has played against Gary Cahill at club level. During his time at Napoli in 2012, he scored in a 3-1 victory over Chelsea but was part of the side that lost to the eventual winners 4-1 after extra time in Stamford Bridge. Only this year, Cavani's PSG was knocked out by Cahill's Chelsea as Demba Ba broke Cavani's hopes of European glory. Perhaps mentally Cahill already has one over Cavani, and will look to continue his good form against him on Thursday.
Despite that, it is a different stage, the World Cup and Cavani has already scored in this tournament, albeit from the penalty spot in a defeat to Costa Rica. He will likely have Suarez up front with him and that is surely to boost his confidence and performance levels. Cahill knows how to stop Cavani, but like Jagielka, will need to be at his very best to do so. Uruguay rely on their forwards a lot for their goal threat, as they both are outstanding, but should England's centre-backs get on top against them then they can feel overall confident of winning this must-win match.
Diego Godin v Wayne Rooney
All the England media attention has been on Wayne Rooney ahead of this must win clash in Sao Paulo. Everybody has been arguing their point whether the Manchester United man should play in his preferred number 10 role behind the striker, or on the left to allow the in-form Raheem Sterling the role. It is no secret that Rooney has never scored a goal for England in the World Cup and there will be no one more aware of that than the player himself.
It is believed Hodgson will choose Rooney to revert back to his favoured position behind the striker, thus giving the striker what he wants. This is only likely to increase the pressure on him to score goals, as he has been given what he wants. Should he play there, Uruguay defender Diego Godin will likely be given the task of handling the threat of Daniel Sturridge and Wayne Rooney. If the Atletico Madrid defender fails to cope with them, Rooney could be allowed to play to his best ability in between the Uruguay defence and midfield. If that occurs, Rooney might just finally score a goal for his country in the World Cup, let's not jinx that though.
One thing is for sure, it is going to be a massive match for both teams in Sao Paulo, one that neither can afford to lose.