Tonight's Group D encounter will be the 11th meeting between the two and both are closely matched looking at the history of the fixture.
In ten previous games, England have won three, while Uruguay have won four with three draws included but the Three Lions won the most recent meeting in March 2006.
England won 2-1 in a friendly at Anfield thanks to goals from two former Reds in Peter Crouch and Joe Cole with Omar Hebar Pouso netting the opening goal of the game for La Celeste that day.
Only Steven Gerrard and Wayne Rooney are a part of the squad this time around from those involved under Sven-Goran Eriksson eight years ago.
Five Uruguayan's from that meeting are in the World Cup squad this time around and four of those were involved in Saturday's 3-1 defeat to Costa Rica with Diego Perez the only man to miss out.
Diego Godin, Diego Lugano, Diego Forlan and Maxi Pereira are all still part of Oscar Tabarez' squad but Lugano will miss tonight's clash through injury and Pereira is suspended after picking up a red card against the Costa Rican's.
Tonight will be the third meeting between England and Uruguay at a World Cup after meeting in 1954 and 1966 with the Three Lions yet to record a win against the South American's in the competition.
La Celeste won 4-2 in 1954 before they drew 0-0 with the eventual winners in 1966.
There have not been more than three goals in the past eight encounters but Uruguay are ready to bring Luis Suarez back into their side despite his lack of fitness.
Suarez and Edison Cavani will have to be kept quiet for England to have the chance of getting all three points in tonight's clash and Roy Hodgson is expected to name an unchanged side from the opening 2-1 loss to Italy.
England can expect to score as they have done in their past eight meetings with South American teams at the World Cup, and although Wayne Rooney has yet to score on the biggest stage, Daniel Sturridge has three in his last four for England.