Three Lions manager Roy Hodgson has retained faith in Manchester United forward Wayne Rooney, who has attracted criticism for his seemingly substandard performance during the 2-1 loss to Italy.
It was Rooney, though, who supplied the vital assist that allowed Daniel Sturridge to convert, bring England back to 1-1.
Rooney may well play centrally, just behind Sturridge, with exciting forward Raheem Sterling on the right and Danny Welbeck on the left.
Providing defensive cover in midfield are Reds duo Steven Gerrard and Jordan Henderson, while Leighton Baines - despite his lapses last weekend - Phil Jagielka, Gary Cahill, Glen Johnson and Joe Hart complete the England starting selection.
England: Hart; Johnson, Cahill, Jagielka, Baines; Henderson, Gerrard; Sterling, Rooney, Welbeck; Sturridge.
They are tasked with taking on Uruguay, who are without Diego Lugano due to injury and Maxi Pereira via suspension - England will therefore be wise to target the understudy right back… Sterling must return a big game performance.
For those who make the starting XI, there is danger-man Luis Suarez at the top, with Paris Saint-Germain attacker Edinson Cavani.
Jose Maria Giminez, a 19-year-old from Atletico Madrid, is a centre back but could be played on the sides. Diego Godin, a veteran of international football and his team-mate at the Vicente Calderon, may slot alongside him in order to take Giminez under his wing. Wingback Alvaro Pereira plays on the left.
Uruguay: Muslera; Gimenez, Godin, Caceres; Pereira Ríos, Lodeiro, Gonzalez, Rodriguez; Suarez, Cavani.