Miguel Herrera's side face the five-time world champions in Fortaleza looking to build on their encouraging 1-0 win over Cameroon last week.
However, Marquez has recognised that Luiz Felipe Scolari's side are an entirely different proposition to the African nation, and the former Barcelona centre-back has talked up the talented Selecao side.
There is one player in particular who Marquez is looking to keep quiet - Barcelona superstar Neymar.
Speaking to Globo, Marquez said: "We have to cover, have two against one, be fast and reduce the spaces on the pitch and not let [Neymar] play.
"Against Brazil, it will surely be a very difficult game. We know the talent of Neymar, Oscar, Hulk but we will train in ways to handle them.
"We have to make the most of this opportunity - it is a showcase for all of us. For many of them it is an opportunity to go up one more level."
Neymar scored twice on his World Cup debut last week, dragging his side back into the match before netting a second-half penalty to give them the lead.
Oscar eventually finished the game off to give Scolari's men the ideal start to their campaign in their homeland.
The 22-year-old Neymar is the big hope for Brazil this summer, but the Barca forward showed no signs of nerves on his maiden World Cup outing, and fans will be looking for more of the same from him against the Mexicans.