The pair were drawn in the same group at Euro 2012 and played in their opening game of that tournament too, with Germany running out 1-0 winners in Ukraine.
Mario Gomez scored the only goal that day, and Germany will hope to win the opener tonight as they have done in the past six World Cups.
Joachim Low and Paulo Bento will both be in the dugouts tonight as they were two years ago, and may field similar lineups.
Holger Badstuber and Gomez are the only two who have not made the German squad this time around that played in the previous meeting, but the starting lineup will likely be much the same as Low has no injury concerns ahead of tonight's clash.
The entire Portugal lineup from the Euro 2012 match have made the trip to Brazil this time around and they will need to get a result to start the tournament well.
The Seleccao have only won one of their past seven World Cup games and will need to change that if they are to get out of the "Group of Death" which also features Ghana and the USA.
Cristiano Ronaldo has declared himself fit for tonight's game and he will need to be at his best if Portugal are to beat Die Mannschaft for the first time since 2000.
They also met at the 2006 World Cup in Germany and the hosts prevailed in the third placed playoff game 3-1 on that day too, with a Bastian Schweinsteiger brace helping them on the way.
It should be a thrilling match with more goals almost a certainty in what has been a great World Cup so far as the Germans scored more goals in qualifying for the tournament than any other European team.
Who will come out on top in tonight's key clash?