The Greek international has been something of an enigma since arriving at Craven Cottage in January.
Despite scoring an impressive 41 goals in 92 appearances for Olympiacos, and arriving for a club-record £12 million fee, a series of injury and fitness problems have dogged his early career in London. He made just three Premier League appearances as Fulham suffered relegation to the Championship.
Although he hardly featured for the Cottagers, he was still called up to the Greek national team for the 2014 World Cup, and the 26-year old may have been hoping to impress on the world stage to interest any potential suitors.
However, Greece lost their first group game 3-0 to Colombia, and the highly-rated forward featured for just 26 minutes, with Theofanis Gekas preferred as the lone striker in Fernando Santos' 4-5-1 formation.
When Mitroglou arrived on the pitch in the 64th minute, he may have been hoping he could turn around the then two-goal deficit in Ethniki's favour.
Unfortunately, Mitroglou failed to have a noticeable impact upon the game, recording just one shot - which happened to be off target - and failing to record any key passes, successful dribbles or draw any fouls.
Although his lack of chances may be attributed to the Greek style of defence, the striker in this formation is required to drop deep and provide the link-up play between the central midfield and the wingers. However, Mitrogolu struggled to get involved, completing just 10 passes in his spell on the pitch.
If Fulham do plan to offload their record signing this summer in an attempt to reduce the wage bill - an act that seems likely with the increasing attempts to sign Ross McCormack from Leeds United - they will be disappointed that Mitroglou is not impressing on the world stage.
It is likely that his departure will be at a fraction of the £12m that Fulham paid to bring him to Craven Cottage, meaning that, having rested their hopes of Premier League survival on him, Mitroglou would have hurt Fulham both in terms of their status, and in their financial security.