Defender Shkodran Mustafi has been called up from the standby list after the Dortmund star's ankle injury.
After seeing one of his most potent attacking players suffer an injury that would rule him out of the World Cup in Brazil, Germany boss Joachim Low has taken the unusual decision of plumping for a relatively unproven centre back with just over 50 professional appearances and only 1 international cap to replace him.
When Marco Reus hit the turf with what looked like a serious ankle injury, German the nation, whose team are one of the favourites for the tournament, were likely holding their breath and hoping for the best.
But as the 25-year-old left the field in tears Low may have already been preparing for who he would replace the Dortmund star with. And plumping for Mustafi is unlikely to have settled the nerves back in Berlin.
Germany had already suffered one midfield injury in the lead up the tournament, with Bayer Leverkusen's Lars Bender being ruled out from the squad after injuring his thigh in the post season training camp in Italy, but Reus' absence will be a quite catastrophic blow after the winger enjoyed a superb Bundesliga season that has seen him linked with Manchester United and Barcelona.
"For him and for us this is extremely regrettable," said Low said on Reus' injury, with the news it would likely rule him out for six or seven weeks.
The Germany boss went on to address his decision to call up a defender in place of an attacking player: "It is not about us replacing Marco Reus one on one.
"Our quality in the position behind the strikers is very high. We have Lukas Podolski, Andre Schurrle, Mario Gotze, Thomas Muller, Mesut Ozil, Julian Draxler and Toni Kroos to give us plenty of alternatives.
"That's why we decided for another option for the defensive area. Shkodran impressed us in training camp, he's fit, we have confidence in him."
Only just 22-years-old, Mustafi made one lone appearance for the Toffees in his three years at the club, a substitute appearance in the Europa League in 2009. After moving to Serie A in 2012 he broke into the first team at Stadio Luigi Ferraris several months later, and made a decent 31 appearances this last season.
Though the defender only made his debut for Low's Germany against Poland recently, he has been well represented at every youth level for his country, and it looks like the European giants managed to spot something in him that David Moyes, who released him at Everton, didn't.
Can Germany still win the World Cup without Reus?