The second game in World Cup Group D could be crucial as 2006 winners Italy take on England in Manaus.
Both sides are preparing to do battle in hot and humid conditions knowing that a winning start to their campaign could be invaluable.
Group D is a stern test for Italy with England, Uruguay and Costa Rica standing in the way of progress to the last 16.
Many pundits in Italy believe that the Azzurri could either go all the way or be stopped at the group stage this time around.
AC Milan man Mario Balotelli is expected to be used as a lone striker with Andrea Pirlo and Marco Verratti behind him.
The Italy boss controversially chose to drop Fiorentina striker Giuseppe Rossi despite his prolific start to the Serie A season because he didn't believe the ex-Manchester United man had fully recovered from a knee ligament injury in January.
Antonio Cassano will be rested and defender Andrea Barzagli is fighting off a fever, so Gabriel Paletta could accompany Giorgio Chiellini with Ignazio Abate and Mattia De Sciglio on the wings.
This is the ninth time Italy have faced Luxembourg. The Azzurri have won every game so far, scoring 24 times and conceding just once.