The small forward lit up the fourth quarter as Indiana triumphed over the Heat and fended off elimination.
The small forward scored 37 points, with 21 coming in the fourth quarter in what was the most incredible display of shotmaking seen in this year's playoffs so far.
His most important shot came with the Pacers up by one with just over a minute remaining, after the Heat had rallied back. George made a three from the left wing to extend the lead to four, and Indiana held on to stay alive in the series.
George fell two points shy of his playoff career high, and was four short of Reggie Miller's playoff record for the Pacers.
"I just felt it. I felt in rhythm. I had to be aggressive," George said. "I tried to come out and be aggressive to start this game off, and I was getting looks. I got hot."
James finished with just seven points on 2-10 shooting after battling foul trouble in the first three quarters. The four-time MVP struggled to find any rhythm when he re-entered the game, and George capitalised with his most impressive display of the series.
The battle between the two stars was a microcosm of the game as a whole. Miami, so dominant since losing Game 1 of the series, were disrupted throughout the second half by Indiana's swarming defense.
The Pacers forced 17 turnovers and converted many of them into fast break points as Miami were unable to find any tempo.
The game was in danger of being overshadowed by the antics of Indiana guard Lance Stephenson. Stephenson was, as ever, looking to get into the heads of Heat stars James and Dwyane Wade, but arguably went too far in poking his head into coach Erik Spoelstra's huddle.
The Pacers guard will argue that his shenanigans paid off, as they resulted in James's worst performance against Indiana to date. The series will now head back to Miami as Indiana attempt to bring it home for Game 7 while the Heat look to close it out for good.