There are reports in Italy that Inter and Tottenham could exchange unsettled talents ahead of next season.
Guarin is expected to leave Inter during the summer after attempting to leave the club in January but failing.
The talented 27-year-old made no friends in the Inter faithful by agreeing a move to rivals Juventus, which then fell through and left him stranded.
Inter are expected to find a new employer for Guarin and the move could tie in nicely with their desire to sign Erik Lamela.
Argentine forward Lamela was a star at Roma and joined Tottenham for huge money, but last season was something of a disaster.
Having struggled to settle in London and been hindered by injury problems, Lamela has been widely linked with a return to Italy.
However, it has also been reported in Italy that new Tottenham manager Mauricio Pochettino will be keen to give Lamela more opportunities in North London.
Guarin's future may only be decided after the World Cup, which Inter will hope will give him a chance to increase his value.