Spurs finally put an end to weeks of rumours by announcing that Saints boss Pochettino would be the man to replace Tim Sherwood at White Hart Lane, giving the Argentine a five-year contract after superb work on the South Coast in his almost 18-month stay at the club.
With the former Espanyol man now set to start work in North London, the attention will turn to how Spurs will conduct their transfer business this summer. The £100m signings a year ago were a disaster, yet despite that, chairman Daniel Levy will again back his manager with a healthy transfer budget.
Pochettino made only three signings at St. Mary's Stadium, bringing in defender Dejan Lovren, midfielder Victor Wanyama and striker Dani Osvaldo, and whilst the latter struggled to make much of an impact in England, Lovren and Wanyama established themselves as key players under Pochettino.
With more money to spend at Spurs, he may venture into the transfer market with more regularity - which could include swoops on his former club. His success at Southampton will lend itself to targeting some of his former players, with forward Rodriguez a potential target that makes sense.
The former Burnley man showed great progress in his second season with the Saints, hitting 15 goals in just 33 appearances, earning England recognition in the process. He was set to make a push for the World Cup squad until he suffered a torn anterior cruciate ligament injury in the final weeks of the season - which means he won't be fit until around October or November.
That could deter Spurs from making a move, but Rodriguez, 24, would be given time to recover at White Hart Lane as they already have players who can fill in until he's healthy. With his ability to play out wide or up front, Rodriguez would add some much needed quality to a Spurs frontline which struggled at times this season - and Pochettino knows how to get the best out of him.