Chelsea are backed to open the title race with a win over Liverpool while Arsenal could thrash Newcastle. Everton, Sunderland and Manchester United should also win.
And here they are...
Southampton v Everton: 1-2
Everton may have mopped the floor with United last week but there will be no such easy ride at St Marys.
Saying that Mauricio Pochettino’s men really have nothing to play for other than pride and World Cup places now - while Everton are focused on making the Champions League after their recent setback v Crystal Palace.
A close game - but Everton could nick it.
Fulham v Hull: 2-2
Hull are another team who have switched off in the league - and been dragged perilously close to the relegation fight as a result.
Fulham on the other hand need no reminding how close they are to the battle - but Felix Magath has revived them of late.
A score draw seems likely between these two outfits.
Stoke v Tottenham: 1-0
Spurs beat Fulham last week almost exclusively because of Christian Eriksen’s set-piece delivery.
Stoke are tough anywhere, but tougher at home, and this disjointed Sherwood rabble are likely to come unstuck when faced with the Potters.
Swansea v Aston Villa: 1-1
Two evenly matched sides who are both just flirting with a dogfight.
A tight affair predicted and a draw the consequence - but who knows at this point in the season.
West Brom v West Ham: 1-2
The Hammers are almost safe, but The Baggies are far from it and after this weekend I think they might be even further back.
Sam Allardyce can take his team to the magic 40 points this weekend with a win - and he will want his players to attack that prize like a wounded animal.
Manchester United v Norwich: 3-1
What a week it has been for United - and you have to feel sorry for Norwich.
They come up against a United team full of belief after the sacking of Moyes and internship of Ryan Giggs.
An easy win is expected.
Sunderland v Cardiff: 3-2
Expect goals? Perhaps - but expect the loser to be all but relegated - absolutely.
For me Sunderland are the better team and their recent win against Chelsea will have spirits soaring.
This might be the death knell for Ole Gunnar Solskjaer’s side.
Liverpool v Chelsea: 1-2
Am I mainly saying this in hope rather than expectation? Maybe - but a Chelsea win would really throw the cat among the pigeons.
Liverpool have to lose eventually right?
And Chelsea have already done this once by heading to The Etihad and silencing Manchester City.
Crystal Palace v Manchester City: 1-1
Meanwhile I can see ‘glad all over’ Palace fans singing again this weekend - as Tony Pulis works a masterclass over City.
Pellegrini’s boys will have enough to score - but I don’t think enough to win, as the title slips through their fingers.
Arsenal v Newcastle: 5-1
Monday Night football now and quite frankly it is hard to look beyond an Arsenal win in this one.
The Newcastle players can already feel the sand between the toes, smell the suntan lotion and taste the sangria - they have been poor in 2014.
The Gunners should have a field day.