One area, in cup matches especially, which often sees players miss out regards loan players.
Indeed Wigan are without Rob Kiernan and Martyn Waghorn - but four other top names are all in contention for a starting spot.
Josh McEachran, Nicky Maynard, Jack Collison and one other player - one who will hope to be taking on Arsenal many more times in his career - will be in contention for the game.
That player is Nick Powell.
The attacking midfielder is on loan at the club from Manchester United - where he will be hoping to have an impact next season after an impressive spell out on loan this term.
It has been a struggle for the player recently however - he recently missed two months of the season with a hamstring problem - but he is back and ready for action with Uwe Rosler’s side.
And if he produces anything like his previous visit to Wembley - well Wigan are in for a fun day out.
The last time he featured at the home of football was in May 2012 - just weeks before he joined United for a fee in the region of £6 million.
That was for Crewe Alexandra in the League Two play-off final against Cheltenham Town - when he produced this moment of absolute magic…
Powell knows the world’s eyes will be watching him in action this weekend - and that many a United fan will want to see him dumping their old foes out of the competition.
So a repeat of his last Wembley performance would certainly go down well back at his parent club.