Liverpool, Manchester United, Everton, Manchester City and Chelsea are all backed for big wins.
Here they are...
Manchester City v Southampton: 3-1
Southampton are probably one of the last teams you want to face if you are in a title race.
But Mauricio Pochettino has a fearless side - and that could prove their undoing against a ruthless City side.
Aston Villa v Fulham: 1-1
Villa have lost firepower in the injury to Christian Benteke - and seem to be on their holidays already after beating Chelsea 1-0 recently.
Fulham are fighting relegation and this could prove a vital point for them.
Cardiff v Crystal Palace: 2-1
A really tough one to call but on nothing more than just gut instinct I will give the win in this game to the home side.
Hull v Swansea: 2-2
Two sides who should be safe - but are not quite there yet.
Evenly matched, and a draw is a likely outcome.
Newcastle v Manchester United: 1-3
Talking of teams that have gone on their holidays…?
If Newcastle play like they did against Southampton last week then regardless of the Champions League tie distraction United will tear them apart.
Norwich v West Brom: 2-0
Carrow Road must play a pivotal part if Norwich are going to stay in the Premier League this season - and this would be a massive result for The Canaries.
It would however be catastrophic for The Baggies.
Chelsea v Stoke: 3-0
Chelsea are scorned, of that there is no doubt - and Jose Mourinho will expect big things from his side against a Stoke side who are essentially playing for their wages at the moment - after recently securing Premier League survival.
Everton v Arsenal: 2-1
The weekend’s big game comes from Goodison Park - where The Toffees look to go within a point of fourth spot and the Champions League.
Roberto Martinez’s side have the ability to beat The Gunners and I think they will do just that.
West Ham v Liverpool: 0-2
Many are predicting Liverpool’s wheels to tumble off their wagon this week.
The Hammers represent the type of immobile defensive side they tear through like ribbon - this should be comfortable.
Tottenham v Sunderland: 1-1
Maybe I just don’t like Tim Sherwood? Wait no that is definitely what it is - but I don’t want him to win this weekend.
With that in mind I also don’t think he will as relegation threatened Sunderland scrap away.