The French giants got the better of Jose Mourinho’s side 3-1 in the first leg at Parc des Princes in Paris on Wednesday and are now favourites to go through to the semi-finals.
Lavezzi himself scored the opening goal of the night after just three minutes with a sensational first-time effort.
Javier Pastore replaced his Argentine compatriot Lavezzi in the 85th minute and in the third minute of injury time dealt a hammer blow to Chelsea’s hopes when he got the better of three defenders to slam home past Petr Cech to make it 3-1.
Chelsea have their work cut out in the second leg even with the likely absence of striker Zlatan Ibrahimovic due to injury.
And Lavezzi is confident that the Premier League outfit will not pose any challenge for them at Stamford Bridge next Tuesday.
“I'm not worried about Chelsea pulling off a repeat of their comeback against Napoli because this is a completely different team and we hope to through,” UEFA’s official website quotes the 28-year-old as saying.
The Argentina international forward was referring to the clash between Chelsea and Napoli in the last 16 of the Champions League in 2011-12.
On that occasion, Lavezzi scored twice in the first leg as Napoli humbled the Blues 3-1 in Naples and were favourites to reach the quarter-finals.
However, under the guidance of Roberto Di Matteo, the London outfit staged a scintillating comeback in the second leg, winning it 3-1 before going on to clinch the tie in extra time.
Can Chelsea do something similar this time around? Midfielder Ramires certainly thinks so, even though he will be suspended for the match at Stamford Bridge.
“It's difficult, totally different,” said the 27-year-old. “We need to score two goals to go through, but it's not impossible. Paris have a great team, but we will be playing at home in front of our fans. Unfortunately we lost, but we have to keep our heads up for the next match.
“We can't say that [PSG] are better than [Napoli in 2011-12]. We played against Napoli and we won, and now we will have 90 more minutes to play against Paris. It's no use saying who is stronger; we have to show on the pitch that we deserve to win.”