Real Madrid had gone 31 matches unbeaten prior to the Clasico on Sunday, and now they have lost two La Liga matches in a row.
From having the prospect of going seven points clear of their arch-rivals Barcelona, Los Blancos have slipped two points behind them in third.
Yet coach Carlo Ancelotti remains defiant and is confident that his side will recover from their setback against Sevilla on Wednesday.
“I don't think the defeat affected us,” the Italian told the club's official website.
“Before everything was going well and now we have arrived here. Now we need to react with everyone's character and personality.
“The league is more complicated and all the matches will be important.”
It looked to be going well for Madrid at the Ramon Sanchez Pizjuan when they went 1-0 up in the 14th minute through Cristiano Ronaldo.
However, Sevilla have a strong record at home and are fighting for a top-four finish, so it was not a great surprise when they restored parity through Carlos Bacca just five minutes later.
Ronaldo continued to trouble the hosts with his free kicks and attacking forays, but it was Bacca who scored the winner 18 minutes from time.
This was Madrid’s second successive following their 4-3 home loss to Barcelona on Sunday, but Ancelotti believes that they deserved at least a draw.
“I don't think we deserved to lose,” claimed the 54-year-old. “On one hand, we could have because we didn't prepare well for Sevilla's counter-attacks and that is how they scored both goals.
“We took the lead and could have scored more goals. Then they scored two goals in the same way when we needed more balance”.
Does Ancelotti have a point? Perhaps.
Real had 69% of the possession, 26 shots of which eight were on target and nine corner kicks. In contrast, Sevilla had the ball just 31% of the time, three shots on target and only two corner kicks.
The stats were in favour of the Madrid giants, but the fact is that Sevilla took their chances and they did not. And that’s what cost Madrid three valuable points.