Here are the sides Manchester United and Olympiakos have selected this evening. Kick-off from Old Trafford at 19:45 GMT.
Manchester United: De Gea, Rafael, Jones, Ferdinand, Evra, Valencia, Carrick, Giggs, Welbeck, Rooney, Van Persie
Subs: Lindegaard, Fellaini, Fletcher, Januzaj, Kagawa, Young, Hernandez
Olympiakos: Roberto, Maniatis, Holebas, Manolas, Marcano, Leandro Salino, N'Dinga, Perez, David Fuster, Campbell, Dominguez
Subs: Megyeri, Papadopoulos, Bong, Paulo Machado, Samaris, Valdez, Vergos
This is a huge match for David Moyes for several reasons.
His side trail 2-0 from the first leg and the magnifying glass will once again be out following a disappointing display in the derby against Liverpool last weekend.
This realistically remains United’s best chance to get into the Champions League next season and if they can put up a strong performance and win by three goals, it will give them confidence heading into the next round.
However, should Moyes’ men lose, the pressure to axe the boss will be at its greatest so let’s hope that the side he has selected can do the business.
For Olympiakos the job is simple, spoil the party. It’s also a great chance for Arsenal’s Joel Campbell to play well in the country he could be playing his league football in next season.