Chelsea may feel they have a strong enough squad to cope with both competitions but it will still be a tough ask for them to get the required league results, especially immediately following a midweek Champions League tie.
What goes against Jose Mourinho's is that Chelsea do not possess a strike force capable of scoring the goals on both fronts, and some may argue even on one. Just witness the Aston Villa debacle.
Eto'o has done well sporadically yes, but he can't be expected to lead the charge on the domestic and European stage at his age.
Torres will never be the Liverpool Torres so there isn't much hope there either. A player that's confidence will forever remain shot it seems.
Demba Ba? I'll leave it there.
Liverpool and Manchester City have only the Premier League to focus on and that gives both sides a massive advantage over Chelsea, who will naturally feel greater physical and mental drain after playing more games.
At least Arsenal remain engaged in the FA Cup and are now favourites to win the competition. That will no doubt distract the Gunners so there is some hope there for the West London outfit.
Perhaps Mourinho's know-how will be enough of a compensating factor in the Premier League title race. He has experience of winning it, which Brendan Rodgers and Manuel Pellegrini don't. Its been ten years since Wenger finished top but you sense he may have lost that winning mentality after going a decade without a single trophy.
However the run-in pans out for Chelsea they should be given their due if they are capable off pulling a Premier League triumph while going further in the Champions League. It's an unlikely scenario though.
Do you believe Chelsea can win the Premier League with Champions League distractions?