The Canaries arrive at St. Mary's having won just one of their last six games, and find themselves 15th in the Premier League table.
Southampton go into the game without Jack Cork, who was substituted with an injury after falling awkwardly on his ankle after jumping for a header against Crystal Palace at Selhurst Park last weekend. Pochettino says the Englishman will be out for "a few weeks".
His natural stand-in, Victor Wanyama, has also been sidelined with a recurrence of the leg injury that ruled him out for two months. In Southampton's Premier League clash with Aston Villa in December 2013, the Kenyan midfielder suffered a fractured bone in his leg, which has led to him having to play catch-up with the rest of the squad in terms of fitness and match sharpness.
Kelvin Davis continues to be unavailable for selection with a back problem.
Influential Croatian defender Dejan Lovren was ill earlier in the week, but is expected to start alongside José Fonte in Pochettino's starting line-up.
PREDICTED STARTING XI: Boruc; Clyne, Fonte, Lovren, Shaw; Schneiderlin, S. Davis; Gastón, Lallana, Rodriguez; Lambert.