The Liverpool loanee made one particular stop that stood out to deny a long-range strike from Jackson Martinez, who was the only man to beat Reina on the night after scoring a deflected half-volley later in the game.
But that wasn't the only impressive stop the Spaniard made on the night, going on to deny the hosts on numerous occasions. Indeed, were it not for 31-year-old, the Serie A side might not be in the Europa League tie at all.
As it stands, Rafa Benitez's men still have a strong chance of going through with just a 1-0 deficit.
But could Reina's performances also have implications for the Reds? The goalkeeper himself recently stated that only Liverpool boss Brendan Rodgers can decide on whether he will return to Anfield - but Reina might just be giving him some food for thought with his performances.
It appears unlikely the 31-year-old will play for Liverpool again, with Rodgers appearing keen on sticking with current no.1 Simon Mignolet, a decision backed by the majority of Reds fans.
If Liverpool make the Champions League next season, however, their coach might decide that some goalkeeping competition would be nothing but healthy - especially if Reina keeps turning out performances like last night's.
Should Liverpool give Reina another chance?