Tottenham suffered an unsatisfactory loss to Benfica last night, and the fear is there is worse to come.
While former midfielder Jermaine Jenas pointed out as an ITV pundit that a win over Arsenal can turn everything around at the club, which is true - but the opposite could see them head into full crisis mode.
Their prospects for winning the all important grudge match appear to have been dealt a blow, in the wake of comments from Tim Sherwood post-game.
Telegraph reporter Henry Winter quoted via Twitter that both Sandro and Kyle Walker have a chance of missing the visit of the Gunners.
Walker and Sandro both started the game against the Portuguese league leaders, but were withdrawn in the second half and with Arsenal looming in three days time it's certainly worrying.
Both players would be certain starters against the Gunners if fit, while Kyle Walker had only just returned from a lay-off last weekend.
It means a huge test for Kyle Naughton, who would come in for the man who hit the winner in the North London Derby at White Hart Lane two seasons ago, and a chance for him to prove why he feels he deserves to be a first choice right-back in the Premier League.
Sandro's absence would certainly be a blow, although the Brazilian's form has not been as superb as it was last season prior to his ACL injury.
The precise nature of both player's injuries has not yet been divulged, but with a quick turnaround time, anything more serious than just a knock will leave at risk of missing the fixture.
Arsenal themselves have problems with key players Mesut Ozil, Theo Walcott, Aaron Ramsey also missing through injury, but the recent back-to-back defeats suffered by Tottenham certainly makes them more vulnerable to being without key men.