The Dutchman suggested that the star striker is disillusioned with life at Old Trafford but the Manchester United boss insists there is no truth to the comments.
Indeed, Moyes said he went to watch the Netherlands' latest friendly and travelled back to England alongside Van Persie, where he couldn't see a problem.
And the Scot also hit out at De Boer personally, asking how he could possibly know how the 30-year-old feels.
“I couldn’t reply to that and I wouldn’t know how Ronald de Boer would know that,” Moyes told reporters.
“I travelled back from the game with him [van Persie] the other night. I went to the Holland game, watched them play and I travelled back with him.
“I hardly feel I need to answer the question, because I don’t know how to answer it.”
The 50-year-old did admit, however, that Man United must improve their current form, expressing deep dissatisfaction with the club's season so far.
"We need to play better," he said. "I think the Olympiakos game [a 2-0 defeat in the Champions League] was the poorest we’ve played. That was disappointing but we’ll improve from that and we will be better.
“We had a bad night and we all take responsibility for that. I refute that was the worst night or all those sort of things.
“We didn’t play well, we said that honestly and we know we have to do much better. The players are aware of that and we will have to do better in the coming months.
“We’ve a big month – three big home games, one of them is the Champions League game – but I think they have been used to that here.”
image: © Doha Stadium Plus