Manchester United, Chelsea, Crystal Palace and Norwich City are backed to win - while Fulham and Cardiff could do each other no favours with a draw.
It might be a reduced schedule in the Premier League this weekend but that doesn’t mean we should take the games on show lightly.
Manchester United and West Brom’s managers need wins to relieve respective pressures, Cardiff and Fulham face off in a relegation scrap while Norwich also need a win in that respect against Stoke.
Meanwhile the London clash between Chelsea and Spurs is certainly one to watch.
So how do we think they will get on?
Here are our predictions ahead of the weekend fixtures…
West Brom v Manchester United: 1-2
The Baggies did the business against United at Old Trafford - but that was under Steve Clarke - not this Pepe Mel outfit.
He does not seem to have changed things at all at the Hawthorns - if anything they look worse now than they did before.
United are playing poorly - but in this must win game - I think they will do just that.
Cardiff City v Fulham: 1-1
The writing, I am afraid, appears to be on the wall for these two teams - and the poor management of the clubs hierarchy has to be a major reason in the dire straits they find themselves in.
Neither side look capable of winning this game in my book - so a daw that does no favours seems likely.
Crystal Palace v Southampton: 2-1
Southampton have been great this season - but this seems like the type of game they might just lose.
Pulis has done wonders with Palace since taking over - and the style of play he has implemented at Selhurst Park might just do enough to fight off the relentless pressing style of Mauricio Pochettino this weekend.
Norwich City v Stoke City: 2-0
The defeat to Aston Villa was highly disappointing - especially after the win against Tottenham Hotspur the previous week.
That being said I believe Norwich will stay up - and these are the type of games they need to win if they are to do so.
Chelsea v Tottenham Hotspur: 3-1
Don’t listen to Jose Mourinho - Chelsea are definitely title contenders.
Spurs come with a good away record, but let’s just say that Jose Mourinho’s at Stamford Bridge is better.
image: © Ronnie Macdonald